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Če se človek na ta način še naprej "spodbuja", se možgani postopoma prilagajajo umetno povišani ravni dopamina, hkrati pa ga sami proizvajajo v manjših količinah. To spodbuja odvisnika, da poveča odmerek, da bi vrnil prijetne občutke, saj evforija nenadoma popusti depresiji in depresiji.
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